Parkinson Disease: An Update<FEFF>
نویسنده
چکیده
P arkinson disease is a progressive neurodegenerative disorder that is pathologically defined by degeneration of the dopaminergic neurons in the substantia nigra and development of Lewy bodies in the residual dopaminergic neurons. Pathologic changes may be detected up to 20 years before the onset of motor symptoms, and are accompanied by a clinical prodrome of nonspecific symptoms such as hyposmia, constipation, and fatigue. The disease affects approximately 1 percent of persons older than 60 years, and up to 4 percent of those older than 80 years.
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